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Time-course transcriptomic analysis of a panel of MET receptor tyrosine kinase-inhibited gastric cancer cell lines
Overview
Dataset Name :
Time-course transcriptomic analysis of a panel of MET receptor tyrosine kinase-inhibited gastric cancer cell lines
Description :
Gastric cancer cell lines (KATO II, Snu-5, MKN45 or OKAJIMA) were treated for a range of times between 2 h and 24 h with vehicle or 0.1 µM PHA-665752 (PHA665), a MET-specific small molecule inhibitor.
Dataset Type :
Transcriptomic
Release Date :
December 10, 2015
DOI :
10.1621/fl1TWZZjRA
Version :
This is Version 1.0 of an annotated derivative of the original dataset, which can be found in GSE54532
Dataset Citation :
Lai A and  Park M (2014) Time-course transcriptomic analysis of a panel of MET receptor tyrosine kinase-inhibited gastric cancer cell lines, v 1.0 Signaling Pathways Project Datasets. 10.1621/fl1TWZZjRA
Download Citation :

Associated Article :
Lai AZ, Cory S, Zhao H, Gigoux M, Monast A, Guiot MC, Huang S, Tofigh A, Thompson C, Naujokas M, Marcus VA, Bertos N, Sehat B, Perera RM, Bell ES, Page BD, Gunning PT, Ferri LE, Hallett M and Park M (2014) Dynamic reprogramming of signaling upon met inhibition reveals a mechanism of drug resistance in gastric cancer. Sci Signal 7 ra38 View Abstract | View PubMed
Dynamic reprogramming of signaling upon met inhibition reveals a mechanism of drug resistance in gastric cancer.

Experiments

There are 20 Experiments for this dataset. Up to the 50 up and down p < 0.05 FDR data points are displayed for each. Please download the dataset to view all data points.

  • 1 | PHA665 vs Veh | 0.1 µM, 2 h - OKAJIMA cells
  • 2 | PHA665 vs Veh | 0.1 µM, 4 h - OKAJIMA cells
  • 3 | PHA665 vs Veh | 0.1 µM, 8 h - OKAJIMA cells
  • 4 | PHA665 vs Veh | 0.1 µM, 16 h - OKAJIMA cells
  • 5 | PHA665 vs Veh | 0.1 µM, 24 h - OKAJIMA cells
  • 6 | PHA665 vs Veh | 0.1 µM, 2 h - MKN-45 cells
  • 7 | PHA665 vs Veh | 0.1 µM, 4 h - MKN-45 cells
  • 8 | PHA665 vs Veh | 0.1 µM, 8 h - MKN-45 cells
  • 9 | PHA665 vs Veh | 0.1 µM, 16 h - MKN-45 cells
  • 10 | PHA665 vs Veh | 0.1 µM, 24 h - MKN-45 cells
  • 11 | PHA665 vs Veh | 0.1 µM, 2 h - Snu-5 cells
  • 12 | PHA665 vs Veh | 0.1 µM, 4 h - Snu-5 cells
  • 13 | PHA665 vs Veh | 0.1 µM, 8 h - Snu-5 cells
  • 14 | PHA665 vs Veh | 0.1 µM, 16 h - Snu-5 cells
  • 15 | PHA665 vs Veh | 0.1 µM, 24 h - Snu-5 cells
  • 16 | PHA665 vs Veh | 0.1 µM, 2 h - KATO II cells
  • 17 | PHA665 vs Veh | 0.1 µM, 4 h - KATO II cells
  • 18 | PHA665 vs Veh | 0.1 µM, 8 h - KATO II cells
  • 19 | PHA665 vs Veh | 0.1 µM, 16 h - KATO II cells
  • 20 | PHA665 vs Veh | 0.1 µM, 24 h - KATO II cells
Gene List
Experiment Information
Name : PHA665 vs Veh | 0.1 µM, 2 h - OKAJIMA cells
Description :

Human OKAJIMA gastric cancer cells were treated for 2 h with vehicle or 0.1 µM PHA665, a MET-specific small-molecule inhibitor.

Tissue/Cell line : epithelium, OKAJIMA cells
Species : Human
Additional Information