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Welcome to the Signaling Pathways Project

The Signaling Pathways Project is a multi-omics knowledgemine based upon public, manually curated transcriptomic and cistromic (ChIP-Seq) datasets involving genetic and small molecule manipulations of cellular receptors, enzymes and transcription factors. Our goal is to create a resource where scientists can routinely generate research hypotheses or validate bench relevant to cellular signaling pathways. Learn more »


Browse, cite or download from the SPP archive of biocurated transcriptomic and ChiP-Seq datasets.

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Ask sophisticated questions of the SPP knowledgebase with a few clicks of a mouse: single gene targets, frequent gene targets of receptors, enzyme or transcription factors, GO terms and custom gene lists.

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Check out the Signaling Pathways Project article in Scientific Data.

To catch up on the latest SPP news, please see our Twitter feed.

Mine our universe of biocurated 'omics data points to generate hypotheses, validate data and test models

Browse and filter our biocurated datasets