Error
Your session has expired. Please click "Refresh" to refresh the page.
Analysis of constitutive androstane receptor (CAR/Nr1i3) ligand-dependent transcriptomes in wild type, CAR/Nr1i3 null mutant and human CAR/NR1I3 knockin mouse liver
Overview
Dataset Name :
Analysis of constitutive androstane receptor (CAR/Nr1i3) ligand-dependent transcriptomes in wild type, CAR/Nr1i3 null mutant and human CAR/NR1I3 knockin mouse liver
Description :
Wild type, CAR/Nr1i3 null mutant, and human CAR/NR1I3 knock-in C57BL/6x129Sv mixed-background mouse mice were injected with or without: (1) a single dose of 30 mg/kg body weight CITCO, a human CAR/NR1I3-specific agonist, once daily for 3 days; (2) a single dose of 3 mg/kg body weight TCPOBOP, a potent non-metabolized agonist of murine CAR/Nr1i3, followed by once daily injectons of vehicle for 2 days; and (3) 100 mg/kg body weight Phenob, an agonist for both human and mouse forms of CAR/NR1I3, once daily for 3 days. Livers were collected 6 h after the final injection.
Dataset Type :
Transcriptomic
Release Date :
March 28, 2015
DOI :
10.1621/datasets.01003
Version :
This is Version 1.0 of an annotated derivative of the original dataset, which can be found in GSE40120
Dataset Citation :
Dataset has incomplete record (Missing Pubmed Information)
Download Citation :

Associated Article :
View Abstract | View PubMed

Experiments

There are 9 Experiments for this dataset. Up to the 50 up and down p < 0.05 FDR data points are displayed for each. Please download the dataset to view all data points.

  • 1 | CITCO vs Veh
  • 2 | TCPOBOP vs Veh
  • 3 | Phenob vs Veh
  • 4 | CITCO vs Veh (CAR/Nr1i3 KO)
  • 5 | TCPOBOP vs Veh (CAR/Nr1i3 KO)
  • 6 | Phenob vs Veh (CAR/Nr1i3 KO)
  • 7 | CITCO vs Veh (CAR/Nr1i3 KI)
  • 8 | TCPOBOP vs Veh (CAR/Nr1i3 KI)
  • 9 | Phenob vs Veh (CAR/Nr1i3 KI)
Gene List
Experiment Information
Name : CITCO vs Veh
Description :

C57BL/6x129Sv mixed-background mice were injected with or without 30 mg/kg body weight CITCO, a human CAR/NR1H3-specific agonist, once daily for 3 days. Livers were collected 6 h after final injection.

Tissue/Cell line : whole liver
Species : House Mouse
Additional Information