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Comparative analysis of the amorfrutin A and rosiglitazone (Rosi)-dependent hepatic transcriptomes in a mouse model of diet-induced obesity
Overview
Dataset Name :
Comparative analysis of the amorfrutin A and rosiglitazone (Rosi)-dependent hepatic transcriptomes in a mouse model of diet-induced obesity
Description :
Male C57BL/6 mice at 6 weeks of age were fed a HFD (60% of calories as fat) for 12 weeks to induce obesity and insulin resistance. Subsequently mice were fed an additional 3 weeks with the same HFD and 4 mg/kg/d Rosi, 100 mg/kg/d amorfrutin A, or vehicle.
Dataset Type :
Transcriptomic
Release Date :
November 30, 2016
DOI :
10.1621/Iw9Fidj7Hn
Version :
This is Version 1.0 of an annotated derivative of the original dataset, which can be found in GSE28384
Dataset Citation :
Weidner C (2012) Comparative analysis of the amorfrutin A and rosiglitazone (Rosi)-dependent hepatic transcriptomes in a mouse model of diet-induced obesity, v 1.0 Signaling Pathways Project Datasets. 10.1621/Iw9Fidj7Hn
Download Citation :

Associated Article :
Weidner C, de Groot JC, Prasad A, Freiwald A, Quedenau C, Kliem M, Witzke A, Kodelja V, Han CT, Giegold S, Baumann M, Klebl B, Siems K, Müller-Kuhrt L, Schürmann A, Schüler R, Pfeiffer AF, Schroeder FC, Büssow K and Sauer S (2012) Amorfrutins are potent antidiabetic dietary natural products. Proc. Natl. Acad. Sci. U.S.A. 109 7257-62 View Abstract | View PubMed
Amorfrutins are potent antidiabetic dietary natural products.

Experiments

There are 2 Experiments for this dataset. Up to the 50 up and down p < 0.05 FDR data points are displayed for each. Please download the dataset to view all data points.

  • 1 | Amorfrutin A vs Veh
  • 2 | Rosi vs Veh
Gene List
Experiment Information
Name : Amorfrutin A vs Veh
Description :

Male C57BL/6 mice at 6 weeks of age were fed a HFD (60% of calories as fat) for 12 weeks to induce obesity and insulin resistance. Subsequently mice were fed an additional 3 weeks with the same HFD and 100 mg/kg/d amorfrutin A or vehicle.

Tissue/Cell line : whole liver
Species : House Mouse
Additional Information